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DO YOU KNOW?
Male accounts 78% of AIDS population whereas women accounts 22% of AIDS population.
HELP


Unfortunately, there's no cure for AIDS. People infected HIV expected themselves to die. However, scientific and medical research does found some drugs and vaccines which can relief the patient's illness and make them live longer.

In Topic HIV, you learned that the retrovirus HIV convert their viral RNA into DNA by the process of reverse transcription. Reverse Transcription is performed by the viral enzyme reverse transcriptase. To terminate the DNA-chain of HIV, scientists developed a HIV DNA-chain terminator. These st drugs are further divided into three sections: Protease inhabitors, Non-nucleoside reverse transcriptase inhabitors, and Nucleoside reverse transcriptase inhabitors. Each section of contains different kinds of drugs.

Protease Inhabitors

Non-nucleoside reverse transcriptase inhabitors
Nucleoside reverse transcriptase inhibitors:

These HIV DNA-chain terminators are very genius. Since they appears as the building blocks of DNA (nucleotide base), the RT enzyme mistakenly inserted them into their growing viral DNA-chain. Once these terminators are in the DNA-chain, they stop any other DNA bases to be added, and therefore stop the growth of DNA-chain and the continous replication of HIV replication.
The most common drugs that are proven highly effective are Zidovudine (AZT), Didanosine (DDI), and Crixivan. Followings are brief descriptions of these drugs and how they work.


Zidovudine (AZT)

Scientists developed a RT (reverse transcriptase, an important enzyme that helps the viral HIV to convert their RNA into DNA molecules.) terminator known as AZT. Belong to the class Nucleoside reverse transcriptase, AZT significantly slows down the reproduction of HIV by interfering with RT. Without these enzyme, HIV cannot replicate, and therefore greatly reduces the number of HIV. In fact, in combination with other drugs, AZT minimize the likelihood of passing HIV infection from the mother to the baby. Evidence shown that nearly 85% of HIV patients prolonged life one year after taken AZT pill.

Didanosine (DDI)

DDI is a drug that becomes unstable in the presence of acid. It is also designated to terminate RT. Like AZT, DDI slows down the reproduction of HIV by interfering with RT. In combination with other drugs, DDI decreases the number of HIV, increase the number of CD4 T-cells, minimize the likelihood of infecting HIV-related diseases, and prolongs life.

Crixivan

Crixivan belongs to the class protease inhabitors. It is designed to interfer with protease, an important viral enzyme. Using Crixivan, the number of HIV reduces because they are not able to replicate. It increases patients' CD4 T-cells, and prolongs their life. Patients using Crixivan found it very useful and effective, and that why it's one of the most common RT terminator you can find.